Our cryostat inserts polarize substrates using dynamic nuclear polarization (DNP), and enable a rapid-transfer in the solid-state, followed by dissolution with minimal dilution.
Our injection dock loads 5 mm NMR tubes with aqueous solutions in 500 ms. The injection dock is compatible with both conventional dissolution-DNP and bullet-DNP.
A low-cost small foot-print para-hydrogen generator for use with liquid nitrogen or helium flow cryostats.
Our bullet-DNP systems can be retro-fitted into HyperSense® systems or used in conjunction with cold bore magnets or with readily available flow and bath cryostats.
Bullet-DNP facilitates rapid dissolution of small samples at minimal dilution. Liquid-state 13C polarization levels of 30% have been achieved, with less than 10-fold dilution and only 700 µL of solvent.
See our recent Nature Communications article for further details: DOI.
The inserts are modular, and modules for different nuclei are readily exchanged. Double-resonant versions are under development.
Cernox® sensors and Allen-Bradley sensors to measure temperature and helium level are available, along with affordable controllers.
Sample ejection is fully automated.
Magnetic tunnels to connect the DNP insert to the injection dock are available.
HyperSense is a registered trademark of Oxford Instruments Molecular Biotools Ltd. Cernox is a registered trademark of Lake Shore Cryotronics, Inc.
The injection dock, developed for bullet-DNP, loads aqueous samples into standard 5 mm NMR tubes within 500 ms.
It fits into narrow-bore magnets, and features a solvent reservoir with temperature control, and a pneumatically actuated valve that is opened to release the solution into the NMR tube.
Sealed NMR tube holders enable a rapid NMR tube exchange.
The injection dock is compatible also with conventional dissolution-DNP. A controller with open source firmware and serial/ethernet interface is available.
Our low-cost, co-axial para-hydrogen generators work with liquid nitrogen as an economic coolant, but can be combined with flow cryostats or cold heads if the highest enrichment of para-hydrogen is required. Para-hydrogen can be generated continuously, and stored for later use.